Natural Compound Shows Promise Against Hard-to-Treat Heart Failure

Researchers at King's College London found that urolithin A, a gut metabolite from pomegranates, walnuts, and berries, improved heart function in mice with HFpEF, a condition affecting nearly half of heart failure patients. The compound activates PKGIα via a novel mechanism, reducing heart enlargement and fibrosis. Human tissue tests suggest potential relevance, but clinical trials are needed.